EMBO Member

Frank Bradke

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn | Germany

EMBO 2013

Axon growth and regeneration

Research in our lab has focused on the intracellular mechanisms regulating axon growth during development and after injury with a particular emphasis onto the cytoskeleton. We found that the intracellular mechanisms mediating axon growth during development share similarities with the ones that regulate axon regeneration. The ultimate aim is to reactivate the polarization program in injured neurons to elicit axon regeneration in the CNS.

Keywords: Axon growth / neuronal polarity / axon regeneration / cytoskeleton

Subject area(s): Cell & Tissue Architecture | Development | Neuroscience