EMBO Member
Centre for Organismal Studies (COS), Heidelberg | Germany
EMBO 2023
We use whole-body connectomics and overlay neuromodulatory networks with single-cell resolution onto synaptic connectomes. We complement this with circuit-wide activity imaging, behaviour, and neurogenetics to study how the sensory environment and the modulatory landscape influence circuit activity. Genome editing and transgenic access to single neurons in Platynereis allow us to link the network output to molecular function at the synapse.
Keywords: Connectomics / ciliated larvae / behaviour / neuropeptides / animal evolution / volume electron microscopy / neural circuits / Platynereis / phototaxis / eye evolution / GPCR evolution
Subject area(s): Signal Transduction | Proteins & Biochemistry | Signal Transduction | Systems Biology | Systems Biology | Development | Neuroscience | Development | Neuroscience | Proteins & Biochemistry | Systems Biology | Signal Transduction | Proteins & Biochemistry | Neuroscience | Development | Systems Biology | Signal Transduction | Proteins & Biochemistry | Neuroscience | Development | Systems Biology | Signal Transduction | Proteins & Biochemistry | Neuroscience | Development