EMBO Member

Gordon Peters

1948 – 2016

EMBO 2002

My laboratory studies the mechanisms through which Polycomb group proteins regulate the INK4a-ARF-INK4b tumour suppressor locus, the most frequent site of genetic alterations in human cancer. The three gene products are each capable of bringing cell proliferation to a halt and their primary role appears to be the implementation of senescence, the state of permanent cell cycle arrest elicited by various forms of stress.

Keywords: Senescence / tumour suppressors / INK4a/ARF / Polycomb complexes

Subject area(s): Chromatin & Transcription | Differentiation & Death | Molecular Medicine