EMBO Member

Jens C. Brüning

Universität, Köln | Germany

EMBO 2012

CNS-dependent regulation of metabolism

Our research focusses on elucidating the CNS-dependent regulation of energy and glucose metabolism through the use of genetically modified mice. These studies revealed a previously unappreciated role for insulin action in the central nervous system (CNS) to control organismal glucose homeostasis and insulin sensitivty.

Keywords: Obesity / energy homeostasis / insulin resistance / CNS insulin action / insulin signalling in the brain / fatty acid metabolism

Subject area(s): Cellular Metabolism | Molecular Medicine | Neuroscience | Signal Transduction