EMBO Member

Karl-Peter Hopfner

Ludwig-Maximilians-Universität, München | Germany

EMBO 2010

Mechanisms of DNA repair and innate immunity

My laboratory studies the molecular mechanisms of the cellular responses to genome instabilty and foreign nucleic acids, in particular, how cellular DNA/RNA sensors distinguish right from wrong or self from non-self. We use a combination of structural, molecular and cell biology to address the structures and mechanisms of DNA double-strand break sensors and repair enzymes, chromatin modifying enzymes and antiviral RNA sensors in the innate immune system.

Keywords: DNA repair / chromatin / innate immune system / genome maintenance / structural & molecular biology

Subject area(s): Genome Stability & Dynamics | Proteins & Biochemistry | Structural Biology & Biophysics