EMBO Global Investigator
National University (NUS), Singapore | Singapore
GIN 2023–2026
Our primary goals are to identify the mechanism of relapse to targeted therapy by studying tumor intrinsic and tumor extrinsic mechanisms. We are performing multi-dimensional studies involving mitochondrial outer membrane potential measurements, multi-omics, and DNA barcoding to model drug-tolerant persisters. We are exploiting human blood cancer cell lines, patient-derived xenograft models, and primary tumors to address our hypothesis.
Keywords: Apoptosis / acute leukemia / personalized therapy / drug resistance modeling / BCL-2 family proteins / drug-tolerant persisters
Subject area(s): Chromatin & Transcription | Differentiation & Death | Immunology | Signal Transduction