EMBO Member

Thomas Sommer

MDC, Berlin | Germany

EMBO 2003

Ubiquitin proteasome system in protein homeostasis

The Ubiquitin Proteasome System is a key element of cellular homeostasis. Central to this process are ubiquitin ligases that modify target proteins with ubiquitin. We analyse their function using biochemical methods to understand the underlying molecular principles. In particular, we focus on protein homeostasis and the involved ubiquitin ligases in the endoplasmic reticulum (ER) in a process termed ER associated protein degradation (ERAD).

Keywords: Ubiquitin Proteasome System / ERAD / selective proteolysis / protein transport / yeast cell biology / protein quality control

Subject area(s): Membranes & Transport | Proteins & Biochemistry